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KMID : 0378019730160090063
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New Medical Journal
1973 Volume.16 No. 9 p.63 ~ p.69
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The Effect of the PHA-Stimulated Lymphocytes from DNCB-Sensitized Rabbit on Growth of Subcutaneously Implanted Ehrlich Carcinoma
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Abstract
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Kim and Kim(1970) in our laboratory reported that the immunotherapy against subaxillary implanted mice of Ehrlich carcinoma with immune lymphocytes from rabbits immunized with live or UV-killed Ehrlich carcinoma showed not only tumor regression but also prolongation of survival of mice bearing tumors. Lee and Kim(1970) also demonstrated lymphocytes from rabbits immunized with the same tumors have a powerful cytocidal effect on target cells in vitro. And they suggested that the immunity of Ehrlich carcinoma is mediated by cell-mediated immune reaction.
It is a well known fact that dinitrochlorobenzene (DNCB) induces delayed hypersensitivity and phytohemagglutinin (PHA) stimulates the transformation of small lymphocytes in vitro. And that Brostoff et al. (1969) demonstrated that the lymphocytes that respond to non-specific stimuli such as PHA was almost all thymus-dependent cells (T-lymphocytes) which may produce and secrete a soluble factor that nonspecifically stimulates the transformation of the lymphocytes.
We made an attempt to observe the tumoricidal activity of PHA-stimulated thoracic lymphocytes from DNCB-sensitized rabbits by means of administration of them into Ehrlich solid tumor bearing mice.
The results were as follows:
PHA-stimulated thoracic lymphocytes from DNCB-sensitized rabbits were no effective in tumoricidal activity.
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